Journal: Epigenetics

Article Title: A global profile of gene promoter methylation in treatment-naïve urothelial cancer

doi: 10.4161/epi.28078

Figure Lengend Snippet: Figure 4. Verification of TRPA1 Infinium HM27 β-value by pyrosequencing. ( A ) Correlation between Infinium methylation score and pyrosequencing of TRPA1 . The R 2 is the Pearson coefficient. The two circled points correspond to the hypermethylated UC specimen and unmethylated NU specimen shown in the pyrogram below. ( B ) Pyrograms of TRPA1 CpG loci hypermethylated in a UC but unmethylated in NU and in vitro methylated 50:50 unmethylated DNA control are shown. The CG loci from the HM27 probe are indicated.

Article Snippet: Beyond elucidation of the biology underlying the development of UC, there is considerable interest in the study of DNA methylation in UC for diagnosis, prognosis, prediction of response to therapy and reactivation by epigenetic therapy., To gain insight into the biology and progression of UC, we used the Infinium HM27 beadchip with 27578 probes with an average of 2 CpG sites derived from 14495 genes to survey the promoter methylome of 101 urothelial (transitional cell) carcinomas (64 superficial, 37 muscle-invasive) with no prior chemotherapy, immunotherapy or radiotherapy for UC and 6 normal urothelium specimens from patients in the seventh decade of life with no history or evidence of UC.

Techniques: Methylation, In Vitro

Journal: Data in Brief

Article Title: SNP-array profiling data from breast cancer patients and healthy women's blood DNA samples

doi: 10.1016/j.dib.2025.111343

Figure Lengend Snippet:

Article Snippet: Subsequently, the DNA samples were subjected to hybridization onto Infinium Asian Screening Array (ASA)’s beadchips.

Techniques: Control, DNA Purification, Extraction, Isolation, Concentration Assay, Microarray, Generated, Gene Expression